Urolithin A

April 8, 2021

Kua whakaatuhia te Urolithin A hei whakaohooho i te mitophagy me te whakapai ake i te hauora o nga uaua i nga kararehe tawhito me nga tauira tawhito o te koroheketanga. I tenei wa, kua whakaatuhia hoki kia whiti i te aarai roro toto, a ka whai pea i nga awangawanga neuroprotective ki te mate o te Alzheimer.

Urolithin A (1143-70-0) ataata

Urolithin A (1143-70-0)Whakatakotoranga

ingoa hua Urolithin He puehu
Ingoa Toi 3,8-dihydroxy-6H-benzo [c] chromen-6-one;

3,8-Dihydroxy-6H-dibenzo (b, d) pyran-6-one;

3,8-Dihydroxyurolithin;

3,8-dihydroxybenzo [c] chromen-6-kotahi;

6H-Dibenzo [b, d] pyran-6-one, 3,8-dihydroxy-;

3,8-Hydroxydibenzo-alpha-pyrone;

CAS Tau 1143-70-0
INCHIKey RIUPLDUFZCXCHM-UHFFFAOYSA-N
Tuhinga o mua C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
rāpoi FTuhinga C13H8O4
rāpoi Wwaru 228.2 g / mol
Ko te Monoisotopic Mass 228.042259 g / mol
ira whakakoero 340-345 ° C
wāhi e koropupu ana  527.9 ± 43.0 ° C (Matapae)
Papanga Flash 214.2ºC
Hawhe-Haiao-Ora Ko te Urolithin A kei roto i te mimi tae atu ki te 48 haora i muri i te inu wai pamekaranete.
Tae Ma ki te beige
STuhinga  DMSO: 20 mg / mL, maama
Stora Tte taumaha  2-8 ° C
Apātai Ka whakamahia hei taapiringa kai me te hua koroheke, ka taea te whakamahi hei whakaiti i te mumura me te whawhai ki te mate pukupuku;

 

tohutoro:

[1] Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). "Te Huringa Metabolic o Ellagitannins: Nga Huarahi mo te Hauora, me nga Tirohanga Rangahau mo nga Kai Hanga Hou". He Arotake Tino i te Pūtaiao Kai me te Kai Tuturu. 54 (12): 1584–1598. mahi: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.

[2] Ryu, D. et al. Ko te Urolithin A ka akiaki i te mitophagy me te whakaroa i te roanga o te tau i roto i te C. ataahua ana ka whakapiki ake i te uaua ki nga kiore. Nat. Med. 22, 879-888 (2016).

[3] "Panui FDA GRAS GRN Nama 791: urolithin A". US Whakahaere Kai me te Tarukino. 20 Hakihea 2018. Tangohia 25 Akuhata 2020.

[4] Singh, A.; Andreux, P. Blanco-Bose, W.; Ryu, D.; Aebischer, P. Auwerx, J. Rinsch, C. (2017-07-01). "Ko te urolithin A-a-waha e ahuru ana ka whakarereke i te koiora me te koiora mitochondrial i te hunga pakeke". Whakahoutanga i te Kaumatua. 1 (suppl_1): 1223–

[5] Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). "Te aromatawai ahuru o te urolithin A, he metabolite i whakaputaina e te microbiota puku tangata i runga i te kai kai o te tipu i ahu mai i nga ellagitannins me te waikawa ellagic". Kai me te Toxicology Matū. 108 (Pt A): 289– doi: 10.1016 / j.fct.2017.07.050. PMID 28757461.