Oleoylethanolamide (OEA) (111-58-0)

March 11, 2020
SKU: 16589-24-5
5.00 i roto i te 5 hāngai ana i runga i 1 whakatauranga kiritaki

Oleoylethanolamide (OEA) ko te agonist kaiwhakarato hāpori perehana engari-aukati (PPAR-alpha). He …… ..


tūnga: I roto i te Production Production
Waea: 25kg / Drum

Oleoylethanolamide (OEA) (111-58-0) ataata

Oleoylethanolamide (OEA) (111-58-0) Nga Taipitopito

ingoa hua Te paura Oleoylethanolamide (OEA)
Ingoa Toi n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

CAS Tau 111-58-0
INCHIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
SMILE CCCCCCCCC = CCCCCCCCC (= O) NCCO
Tātai rāpoi C20H39NO2
Taumaha rāpoi 325.5 g / mol
Ko te Monoisotopic Mass 325.537 g · mol-1
Ko te Whakakuku 59-60 ° C (138-140 ° F; 332-333 K)
Te wai kohua 496.4 ± 38.0 ° C (Matapae)
kiato 0.915 ± 0.06 g / cm3 (Matapae)
Tae paura White
Swhakamamaetanga -20 ° C
Te ngoikore i te taatai ​​me te DMSO He ngoikore
Taupānga Mara Whanui; tāpiringa;

Overview

Ko te Oleoylethanolamide (OEA) me N-Oleoylethanolamide (OEA) he huringa ka hua i roto i te tinana, ka kitea i nga kopu. Ko nga taunakitanga kaha ake e kii ana ka taea e te OEA te mahi ki te neuroprotective endogenous me te whai waahi ki te whakahaere whanonga e pa ana ki te utu. Ano hoki, kua whakaahuatia mai hei kaihauturu peripherally e whakaheke ana i te horahanga o te kai me te kaha o te tinana.

He aha te Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) ko te agonist kaiwhakarato hāpori-ngongo o te peroxisome (PPAR-alpha). Ko te lipid glycolamide e tupu ake ana me te maha o nga waahanga homeostasis ahurei penei i te mana hiahia, te mahi anti-inflammatory, whakaongaonga o te lipolysis me te ngota waikawa momona. Ka taea te Oleoylethanolamide te hormone o te tuaka roro o te kopu. Ko te Oatmeal, he nati, he paura koko ko nga punaha kai nui o Oleoylethanolamide i roto i nga kai. Heoi, ko te nui o Oleoylethanolamide e kitea ana i roto i enei kai he iti (he iti ake i te 2 µg / g).

I te mea ko te reo lipid kaha o te koiora, ka puta mai te oleylethanolamide (OEA) i roto i te kopu me etahi atu kopa, ka whai wāhi ki te ture toenga o te toenga o te momi, te whakarite i te kaakano o te kai me te hinu lipid, penei i te whakahaere i te kai kai me te taumaha tinana. Ko te Oleoylethanolamide he etanolamide waikawa momona (FAE), he taatai ​​monounsaturated o te etanolamide waikawa endocannabinoid (anandamide), me tetahi kaitautoko o te anandamide. He mea nui kia rereke te Oleoylethanolamide mai i te anandamide, he mea motuhake i te kaiwhiwhi o te cannabinoid, me te whakauru i nga mahi koiora na roto i etahi atu huarahi, ma te whakahaere i nga mahi a te PPAR-α hei whakaohooho i te lipolysis. Ko te Oleoylethanolamide he rongoa anti-obesity e kaha ana ki te whakakapi i te CB1 antagonism.

Kua whakaatuhia e nga rangahau preclinical ko Oleoylethanolamide ano hoki te rongoa anti-inflammatory me te pūhui antiioxidant e kaha ana i te mate neuroprotective i roto i te haurangi. Ka taea e te whakahaere uruparenga o Oleoylethanolamide te aukati i te aukati i te waipiro TLR4-whakaohooho i nga kaimati whakaheke toto, na reira ka whakahekehia te tuku o te cytokine proinflamakitika me nga chemokines, nga ahotea oxidative me te nitrosative, a te mutunga ka aukati i te kino o te nerve i roto i te cortex frontal o nga rodents.

Rauemi o Oleoylethanolamide (OEA)

E rua nga punaha o te tiki Oleoylethanolamide (OEA), tetahi mai i nga tipu tipu, ko tetahi ko te haangai tika i roto i te taiwhanga.

Ko Achyranthes Aspera, taketake ki India, Haina me etahi atu whenua o Ahia, e kiia ana kei roto ko Oleoylethanolamide OEA. Ko te raru o te Oleoylethanolamide-a-taiao, ko te tangohanga taara kei te waatea noa, 15: 1 he kiki rongonui, kaore i te rite ki ta te hunga kiritaki, taapiri ranei e whai mana ana. Ae, ka taea e te teitei ake, engari ka tino nui te utu, na reira kaore i tino rite ki te hanga Oleoylethanolamide taiao ma te nuinga.

Ko te puna nui o Oleoylethanolamide kua whakahekehia mai i te waikawa oleic, i waiho hei tuuru o N-oleoyl-phosphatidylethanolamine, ka oti i te N-acyl-phosphatidylethanolamine-selective phospholipase D (PLD) ki te tuku Oleoylethanolamide OEA.

Ko te Oleoylethanolamide he metabolite taiao o te waikawa oleic. Na reira, ko nga kai e taupatupatu ana i te waikawa oleika he puna tuuturu o te OEA.

Me pehea te mahi a Oleoylethanolamide (OEA)?

I roto i nga taangata ngata, ka taea e OEA te whakahaere i te kaainga hau te kaha me te hiahia i te nuinga o te momo whakaurunga tae atu ki te whakahoahoa i nga momo taangata tae atu ki te proliferator-kua whakahoahohia-α (PPAR-α), G-pūmua-whakaurua-whakauru (119) (GPR119) me te kaiwawao o te urunga hou mo te urunga uruwhenua subfamily V (TRPV1). Ae, ka whakahohe e te OEA enei kaiwhakamaapori me te whakaroa i te tiimata o te kai, te whakaiti i te rahinga o te kai, ka whakaheke i waenga o nga kai me te mutunga ka whakarereke te taumaha tinana.

Ano, ko etahi o nga rangahau whakamatau e whakaatu ana ko OEA ano hoki e aukati ana i te whakakitenga o te IL-6, interleukin-8 (IL-8), taarenga whakaheke-kore-1 (ICAM-1) me te taamaha whakakapinga pūtau whanaketanga-1 (VCAM-1) i TNF - me te mumura o te mumura i roto i nga taangata endothelial i roto i nga umbilical urupare i roto i te whakaohooho o nga kaimono mate. I aukatihia hoki e te OEA te ara o te karihi kappa-B (NF-kB). I roto i te rangahau a YT et al, ko OEA (50 µmol / L) i haukotia te tohu VCAM-1 whakaawe a TNF-α i HUVEC.

Ko nga painga o Oleoylethanolamide (OEA)

Ko te paura Oleoylethanolamide (OEA) he pai ki te ngaro te taumaha hei kaiwhakahaere o te hiahia me te tautoko i nga taumata o te cholesterol pai i roto i nga pakeke.

Oleoylethanolamide (OEA) hei kaiwhakapumau Paakete

Ko te aukati i te hiahia me te whakaiti i te whakaputanga o te kai he huarahi pai ki te whakahaere i te toenga o te tinana me te taumaha tinana. Na te mea ko te aukati i te kai he taawewe nui mo te whakapakaritanga o te kaha (kai), ko te whakahaere i te hiahia he mea nui ki te whakahaere i te taumaha o te tinana o te tinana, ina koa ka uru ana ki nga whiringa hauora e whai kiko ana ko te aro ki te whakauru kai tika, taapiringa o te kai, me te mahi.

Ko te taapiri Oleoylethanolamide e awhina ana ki te whakahaere i te haangai lipid, e awhina ana ki te whakahaere i te matekai ma te tuku i nga karere whakaohooho ki te roro, kua whakaatuhia hei awhina i te heke o te triglyceride me nga taumata cholesterol toto.

Oleoylethanolamide mo te whakahaere ngako tinana

Ko te OEA he taonga haumaru peripheral e whakahaere ana i te hiahia me te whakapau kaha.

Ko nga hua o te OEA i akohia i te tuatahi na te mea ka tohaina he rite ki tetahi atu matū, he cannabinoid e mohiotia ana ko te anandamide. Ko te Cannabinoids e pa ana ki te whakato Cannabis, me nga anandamides e tu ana i te tipu (me te mariuana) ka piki ake te hiahia o te tangata ki te ngata ma te kukume i te urupare kai. E ai ki te Wikipedia, ko Oleoylethanolamide te taapiri monounsaturated o te anandamide endocannabinoid. Ahakoa ko te OEA he hanganga matū e rite ana ki te anandamide, he rereke nga ahuatanga o te kai me te whakahaere taimaha. Kaore i rite ki te anandamide, ko te OEA te mahi takitahi i te huarahi cannabinoid, ma te whakahaere i te mahinga PPAR-α kia whakaohooho te lipolysis.

Te whakakotahitanga a Oleoylethanolamide

Kei te rapu te katoa i te hauora ma te whakakorikori tinana i te whare kaukau. Ka tino rongonui te OEA ki nga kaiwhakaatu tinana. I nga waahanga taapiri whakatipu tinana, ko te TTA (tetradecylthioacetic waikawa) he maha nga waihoki e whakamahia ana me te oleoylethanolamide (OEA), e rua hoki te awhina ki te tahu ngako me te whakaheke i te matekai. Ka taea hoki e te TTA te whakatairanga i roto i nga taapiringa anti-momona, na te mea ka tahuna te ngako o te kore mahi; Ko nga hua tuatahi ka kii ko te tinana ka kitea he "tango" i nga momona mai i tana ake kaore i te hiahia ki te tahu kia pau me te whakakori tinana.

Oleoylethanolamide (OEA) ka whakaheke i te triglycerides me te cholesterol, a, i uru tahi me te antagonist cannabinoid, ka poraka te taumaha o te tinana me te whakapai ake i te dyslipidaemia i roto i nga tauira kararehe o te mate taikaha.

Hei taapiri, ko te whakahaere punaha o te oleoylethanolamide kua kitea hei whakarereke i te homeostasis glucose, tae atu ki te tuku insulin me te tohu tohu insulin i roto i nga hepatocytes me adipocytes.

Ko etahi o nga kairangahau e whakaatu ana ko te taapiri oleoylethanolamide he pai nga paanga ki te awangawanga, me etahi atu huarahi me nga taunakitanga hei tautoko.

Me pehea te whakamahi i Oleoylethanolamide OEA

Opānga taha leoylethanolamide

Oleoylethanolamide OEA he hou ki te maakete taapiri, kaore ano kia puta he kino kino. Ko te US Food and Drug Administration (FDA) kaore he awangawanga mo te haumaru o OEA. I roto i nga koiora o ia ra, ko te oleoylethanolamide he waahanga whakaheke taumaha pai, ka whakamahia hei aromatawai i te whānuitanga o te catabolism ki te kopu o te hakihaki, me te awhina ki te whakaheke i te ngako me te kore e aukati.

Oleoylethanolamide tohua

Kaore he horopeta e tohuhia ana mo te nuinga o te roopu oleoylethanolamide mai i te mea kaore ano i te tino rongonui te taapiri oleoylethanolamide me te mea i tona timatanga. Ko te RiduZone te paura OEA tuatahi i whakaatuhia i te tau 2015.

Ko te inenga oleoylethanolamide e tūtohutia ana he kotahi kapo 200mg ka tangohia ana kaore he ranunga

E kii ana te rangahau ka taea hoki e koe te whakaheke, te whakanui ake ranei i nga inenga ia ra ki taau tinana.

100mg mo te taangata 150lb

145mg mo te taangata 200lb

180mg mo te taangata 250lb

Tono o Oleoylethanolamide (OEA)

Oleoylethanolamide paura kua whakamahia i roto i te taapiringa hauora, i hangaia ki te potae Whakaaetanga papa ranei mo te taumaha o te taumaha.

tohutoro:

  • Gaetani S, Oveisi F, Piomelli D (2003). "Te whakatauira i te tauira kai i roto i te kiore na te anorexic lipid kaiwhakarato oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311–6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.

  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Te ture o te whakauru kai ma te oleoylethanolamine". Pūkahu. Mol. Life Sci. 62 (6): 708–16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.

  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks me Daniele Piomelli (2005-12-22). "Ko te pikinga o te nekehanga oleoylethanolamine i roto i te kopu iti o te Pirthon Burmese (Python molurus)". Am J Physiol Regul Integr Comp Physiol. 290 (5): R1407 – R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.

  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Mahuru 2008). "Te haahi o te endocannabinoids me o ratou taatai ​​i te kaha o te whakahaumako me te kai. Te Kai a te Kaha. 13 (3): e42–8. PMID 19011363.

  • Serrano A, et al. Oleoylethanolamide: he paanga ki nga kaiwhakatere hypothalamic me nga peptides ngako e whakahaere ana i te whakaputanga kai. Neuropharmacology. (2011)

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