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Oleoylethanolamide (OEA) (111-58-0)

Oleoylethanolamide (OEA) ko te agonist kaiwhakarato hāpori perehana engari-aukati (PPAR-alpha). He …… ..


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Oleoylethanolamide (OEA) (111-58-0) Nga Taipitopito

ingoa hua Oleoylethanolamide (OEA)
Ingoa Toi n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

CAS Tau 111-58-0
INCHIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
SMILE CCCCCCCCC = CCCCCCCCC (= O) NCCO
Tātai rāpoi C20H39NO2
Taumaha rāpoi 325.5 g / mol
Ko te Monoisotopic Mass 325.537 g · mol-1
Ko te Whakakuku 59-60 ° C (138-140 ° F; 332-333 K)
Te wai kohua 496.4 ± 38.0 ° C (Matapae)
kiato 0.915 ± 0.06 g / cm3 (Matapae)
Tae White
Swhakamamaetanga -20 ° C
Te ngoikore i te taatai ​​me te DMSO He ngoikore
Taupānga Mara Whanui; tāpiringa;

He aha te Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) ko te agonist kaiwhakarato hāpori-ngongo o te peroxisome (PPAR-alpha). Ko te lipid glycolamide e tupu ake ana me te maha o nga waahanga homeostasis ahurei penei i te mana hiahia, te mahi anti-inflammatory, whakaongaonga o te lipolysis me te ngota waikawa momona. Ka taea te Oleoylethanolamide te hormone o te tuaka roro o te kopu. Ko te Oatmeal, he nati, he paura koko ko nga punaha kai nui o Oleoylethanolamide i roto i nga kai. Heoi, ko te nui o Oleoylethanolamide e kitea ana i roto i enei kai he iti (he iti ake i te 2 µg / g).

I te mea ko te reo lipid kaha o te koiora, ka puta mai te oleylethanolamide (OEA) i roto i te kopu me etahi atu kopa, ka whai wāhi ki te ture toenga o te toenga o te momi, te whakarite i te kaakano o te kai me te hinu lipid, penei i te whakahaere i te kai kai me te taumaha tinana. Ko te Oleoylethanolamide he etanolamide waikawa momona (FAE), he taatai ​​monounsaturated o te etanolamide waikawa endocannabinoid (anandamide), me tetahi kaitautoko o te anandamide. He mea nui kia rereke te Oleoylethanolamide mai i te anandamide, he mea motuhake i te kaiwhiwhi o te cannabinoid, me te whakauru i nga mahi koiora na roto i etahi atu huarahi, ma te whakahaere i nga mahi a te PPAR-α hei whakaohooho i te lipolysis. Ko te Oleoylethanolamide he rongoa anti-obesity e kaha ana ki te whakakapi i te CB1 antagonism.

Kua whakaatuhia e nga rangahau preclinical ko Oleoylethanolamide ano hoki te rongoa anti-inflammatory me te pūhui antiioxidant e kaha ana i te mate neuroprotective i roto i te haurangi. Ka taea e te whakahaere uruparenga o Oleoylethanolamide te aukati i te aukati i te waipiro TLR4-whakaohooho i nga kaimati whakaheke toto, na reira ka whakahekehia te tuku o te cytokine proinflamakitika me nga chemokines, nga ahotea oxidative me te nitrosative, a te mutunga ka aukati i te kino o te nerve i roto i te cortex frontal o nga rodents.

He aha te mahi a Oleoylethanolamide (OEA)?

I roto i nga taangata ngata, ka taea e OEA te whakahaere i te kaainga hau te kaha me te hiahia i te nuinga o te momo whakaurunga tae atu ki te whakahoahoa i nga momo taangata tae atu ki te proliferator-kua whakahoahohia-α (PPAR-α), G-pūmua-whakaurua-whakauru (119) (GPR119) me te kaiwawao o te urunga hou mo te urunga uruwhenua subfamily V (TRPV1). Ae, ka whakahohe e te OEA enei kaiwhakamaapori me te whakaroa i te tiimata o te kai, te whakaiti i te rahinga o te kai, ka whakaheke i waenga o nga kai me te mutunga ka whakarereke te taumaha tinana.

Ano, ko etahi o nga rangahau whakamatau e whakaatu ana ko OEA ano hoki e aukati ana i te whakakitenga o te IL-6, interleukin-8 (IL-8), taarenga whakaheke-kore-1 (ICAM-1) me te taamaha whakakapinga pūtau whanaketanga-1 (VCAM-1) i TNF - me te mumura o te mumura i roto i nga taangata endothelial i roto i nga umbilical urupare i roto i te whakaohooho o nga kaimono mate. I aukatihia hoki e te OEA te ara o te karihi kappa-B (NF-kB). I roto i te rangahau a YT et al, ko OEA (50 µmol / L) i haukotia te tohu VCAM-1 whakaawe a TNF-α i HUVEC.

Ko nga painga o Oleoylethanolamide (OEA)

Ka rite ki te haumanu ceramidase, he agonist endogenous o te kaiwhiwhi GPR119, ka whai hua a Oleoylethanolamide ki nga mate o neurodegenerative, anti-atherosclerosis, apoptosis, mamae mamae, whakarei ake i te haangai lipid, me nga pūtau kei runga i nga moutere. He pai te whakamarumaru ki te paruru me etahi atu mate metabolic. Hei taapiri, ka taea e ia te whakaheke i te ngako tinana ma te whakahaere i te hiahia, te whakahaere i te taumaha, me te whakatutuki i te whakaheke taumaha. Ko te Oleoylethanolamide hoki te kaha ki te whakaheke i te mumura me te whakaheke i te taumata cholesterol.

Ko nga whakamahinga a Oleoylethanolamide (OEA)

  • Huawhenua Whakapaunga Kai
  • Gaetani S, Oveisi F, Piomelli D (2003). "Te whakatauira i te tauira kai i roto i te kiore na te anorexic lipid kaiwhakarato oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311–6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.
  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Te ture o te whakauru kai ma te oleoylethanolamine". Pūkahu. Mol. Life Sci. 62 (6): 708–16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks me Daniele Piomelli (2005-12-22). "Ko te pikinga o te nekehanga oleoylethanolamine i roto i te kopu iti o te Pirthon Burmese (Python molurus)". Am J Physiol Regul Integr Comp Physiol. 290 (5): R1407 – R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.
  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Mahuru 2008). "Te haahi o te endocannabinoids me o ratou taatai ​​i te kaha o te whakahaumako me te kai. Te Kai a te Kaha. 13 (3): e42–8. PMID 19011363.
  • Serrano A, et al. Oleoylethanolamide: he paanga ki nga kaiwhakatere hypothalamic me nga peptides ngako e whakahaere ana i te whakaputanga kai. Neuropharmacology. (2011)

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