Te tote waihotanga NADP (24292-60-2)

March 15, 2020
SKU: 164656-23-9
5.00 i roto i te 5 hāngai ana i runga i 1 whakatauranga kiritaki

Nicotinamide adenine dinucleotide phosphate (NADP +) he cofactor e whakamahia ana i roto i nga hohenga anabolic. β-Nicotinamide adenine ……


tūnga: I roto i te Production Production
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NADP disodium te tote (24292-60-2) ataata


β-Nicotinamide adenine dinucleotide phosphate disodium tote (NADP disodium tote) Snga whakaritenga

ingoa hua β-Nicotinamide adenine dinucleotide phosphate disodium tote (NADP disodium tote)
Ingoa Toi Disodium NADP; Ko te disodium phosphate Nadide; NADP; β-NADP; Triphosphopyridine nucleotide disodium te tote;
CAS Tau 24292-60-2
INCHIKey UNRRSQIQTVFDLS-WUEGHLCSSA-L
SMILE C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+]
Tātai rāpoi C21H26N7Na2O17P3
Taumaha rāpoi 787.37
Ko te Monoisotopic Mass 787.039342 g / mol
Ko te Whakakuku 175-178 ° C
Tae Kōwhai
Swhakamamaetanga -20 ° C
Water memehatanga > 50 g / L
Taupānga Coenzyme i roto i te aukatiora aerobic me te anaerobic

He aha te mea β-Nicotinamide adenine dinucleotide phosphate disodium te tote (NADP disodium tote)?

Nicotinamide adenine dinucleotide phosphate (NADP +) he cofactor e whakamahia ana i roto i nga hohenga anabolic. β-Nicotinamide adenine dinucleotide phosphate disodium tote te konupora tote o te NADP +, he tauhohenga e tika ana mo te whakarauora paitini o te huka me te waihuritanga o etahi atu matū. Na ka puta nui i roto i te kiko ora, ina koa i roto i te ate.

Nicotinamide adenine dinucleotide phosphate (NADP) me te NADPH he takahi redox. Ko te ōwehenga NADPH / NADP e whakarite ana i te kaha o te redox intracellular, ina koa ko te urupare anaerobic, na reira ka pa ki te urupare ki te tinana. Ko nga tauira ko te whakahiatini lipid me te waikawa hakihaki Ko te NADP he takirua taatai ​​i roto i nga punaha cytochrome P450 me nga punaha tauhohenga oxidase / reductase penei i te thioredoxin reductase / thioredoxin pūnaha.

Ka whakaratohia e NADPH te whakaheke i nga tauhohenga koiora me te kawe i nga paanga o te redox hei aukati i te whakamate o nga momo hauora react (ROS), na reira ka whakahouhia te glutathione (GSH). Kei te whakamahia ano hoki i nga huarahi anabolic pērā i te waikawa cholesterol me te waikawa momona Whakawhitinga.

Hei taapiri, ko te punaha NADPH hoki te kawenga ki te whakaputa miihini koreutu i roto i nga pūtau ārai mate ma te NADPH oxidase. Ka whakamahia enei maara korekore hei whakakore i nga pathogens i roto i te mahi e kiia ana ko te pakaru o te manawa. He whakaheke ōrite o te puna cytochrome P450 hydroxylated aromatics, steroids, alcohols, me nga raau taero.

Taupānga o β-Nicotinamide adenine dinucleotide phosphate disodium tote

Nicotinamide adenine dinucleotide phosphate (NADP) me te NADPH he takahi redox. Ko te NADP / NADPH he taatai ​​e tautoko ana i te tauhohenga o te reti na roto i te kawenga o te irahiko i roto i te tini o nga tono, ina koa nga tauhohenga anaerobic pēnei i te lipid me te waikawa waikawa. Ko te NADP / NADPH he takirua whakangungu i roto i nga punaha cytochrome P450 me nga punaha urupare oxidase / reductase, penei i te thioredoxin reductase / thioredoxin pūnaha.

Ko etahi atu whākono e whakamahi ana i te NADP hei tauhohenga: Ko te waipiro miraka: Ka whakawhirinaki te NADP; Aromatic ADH: Ka whakawhirinaki te NADP; Ferredoxin-NADP tangohanga; L-Fucose dehydrogenase; Gabase; Ko te whakawhitinga uridyl Galactose-1-phosphate; Ko te dehydrogenase ngatahi; L-Kaitohu paru; Glycerol dehydrogenase: NADP motuhake; Ko te dehydrogenase Isocitric; Enanthate Malic; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase me te Succinic semialdehyde dehydrogenase.

tohutoro:

  • Hashida SN, Kawai-Yamada M. Inter-Organelle NAD Metabolism e pou ana i te Maarama Whakahoki Kaha Hahi NADP i roto i nga otaota. Tuhinga o mua. 2019 Jul 26; 10: 960. doi: 10.3389 / fpls.2019.00960. eCollection 2019. PMID: 31404160. PMCID: PMC6676473.
  • Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M. Ko te paitini o te mate kopa ko te NAD + me te NADP + glycohydrolase me nga tohu o te whanaketanga o te totika.J Biol Chem. 2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Dec 28. PMID: 30593509. PMCID: PMC6398120.
  • Liang J, Huang H, Wang S. Tohatoha, Whanaketanga, Mahi Kiwa, me nga Mahi Hinengaro o te Mate-Hikoi-Mate Hikoi NADH-Whakaheke Whakaheke Ferredoxin: NADP + Oxidoreductase. Tuhinga o mua. 2019 Mar 1; 10: 373. doi: 10.3389 / fmicb.2019.00373. eCollection 2019. PMID: 30881354. PMCID: PMC6405883.
  • Kawai S, Murata K. "Te hanganga me te mahi o te kinase NAD me te phosphatase NADP: nga whaaiao nui e whakahaere ana i te toenga ahuru o te NAD (H) me te NADP (H)". Koiora, Biotechnology, me te Biochemistry. 72 (4): 919–30. doi: 10.1271 / bbb.70738. PMID 18391451.
  • Hanukoglu I. "Te tiaki i nga Huringa Enzyme-Coenzyme i te FAD me te NADP herea Adrenodoxin Reductase-A Ubiquitous Enzyme". Journal of Te Whanaketanga Aukati. 85 (5–6): 205–218. Kupumomo: 2017JMolE..85..205H. doi: 10.1007 / s00239-017-9821-9.PMID 29177972.

TE WHAKAMAHI ME TE KAUPAPA:

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